The NIH Center for Multi-Omics Production

Most human diseases have complex and multifactorial etiologies that are influenced by a combination of genetic and environmental components such as diet, physical activity, exposure to pollutants, and social determinants. To understand disease pathogenesis and advance precision medicine, the flow of molecular information must be studied at multiple levels of omics in parallel. A barrier to progress in the field has been collecting multi-omics data from the same sets of samples and developing collaborative teams with the appropriate expertise to harmonize and integrate the results.

To address these limitations, the Patti and Wang Laboratories have established the Washington University Omics Production Center as part of the Multi-Omics of Health and Disease NIH Consortium. The Washington University Omics Production Center is collecting whole genome sequencing, whole genome bisulfite sequencing, whole genome bisulfite sequencing, ATAC-seq, RNA-seq, proteomics, metabolomics, and lipidomics data from the same set of disease samples provided by NIH Disease Study Sites.